Microbial System
and Computation Biology
Research Team
Research Overview
The Microbial Systems and Computational Biology Research Team is dedicated to unlocking the hidden potential of microbial bioresources deposited in the Thailand Bioresource Research Center, while actively driving its evolution into a Next-Generation Microbial Resource Center powered by data-driven insights and Artificial Intelligence (AI).
By generating holistic, system-level insights, our ultimate goal is to maximize the practical utilization of microbes for agricultural and industrial applications under the challenges of climate change.
In driving the Green Economy, we champion the “Turning Waste to Wealth” paradigm within the energy and environmental sectors. Our research focuses on transforming agricultural and industrial waste, as well as by-products, into next-generation bioenergy, high-value bio-based chemicals, and sustainable environmental bioproducts, actively contributing to global carbon reduction and Net Zero goals.
Our Framework & Approaches
We deliver precision biotechnology and tailored microscopic solutions through 4 strategic core approaches:
- Single Wild-Type Strain: Identifying and harnessing the elite capabilities of native strains with high-performing, specialized traits.
- Synthetic Microbe: Applying synthetic biology engineering to reprogram metabolic pathways and boost microbial production efficiency beyond natural limits.
- Microbial Consortia (SynCom): Designing robust, synergistic synthetic microbial consortia capable of thriving in fluctuating and complex real-world environments.
- Digital Twin of Microbes through Genome-scale Metabolic Models: Constructing virtual microbial digital twins via genome-scale metabolic modeling to accurately predict, simulate, and optimize microbial behavior and metabolic pathways prior to in vitro experiments.
Multidisciplinary Innovation Platform
To accelerate discoveries and deliver precise solutions, our team seamlessly integrates cutting-edge technologies across multiple disciplines:
- High-Throughput Screening: Rapid and intelligent screening platforms to discover high-potential target microbes and functional enzymes.
- Synthetic & Systems Biology: Combining systems and synthetic biology to decode, engineer, and control complex biological networks.
- Omic & Multi-Omics Technology: Utilizing advanced omics platforms (Genomics, Transcriptomics, Proteomics, and Metabolomics) to comprehensively decode microbial biomolecules at all cellular levels, providing precise insights to evaluate and optimize synthetic biology designs.
- Computational Biology & AI: Utilizing computational biology and Artificial Intelligence (AI) to analyze large-scale multi-omics big data and simulate predictive models for accelerated R&D pipelines.
Researcher
Researcher Assistant
